Effect of isopregnanolone on rapid tolerance to the anxiolytic effect of ethanol

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Effect of isopregnanolone on rapid tolerance to the anxiolytic effect of ethanol.

OBJECTIVE It has been shown that neurosteroids can either block or stimulate the development of chronic and rapid tolerance to the incoordination and hypothermia caused by ethanol consumption. The aim of the present study was to investigate the influence of isopregnanolone on the development of rapid tolerance to the anxiolytic effect of ethanol in mice. METHOD Male Swiss mice were pretreated...

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ژورنال

عنوان ژورنال: Revista Brasileira de Psiquiatria

سال: 2006

ISSN: 1516-4446

DOI: 10.1590/s1516-44462006000100005